| ###Banaba leaf extract supplement
--insulin-like action(IR인산화 촉진)
--NK-kb Block
----> dec. inflammation and cell death of panc. islet cell : effective to type I DM also
----> cancer cell apoptosis by Ellagitanin : 자궁암, 유방암, 전립선암, 식도암, 대장암, 피부암, 백혈병 억제
---health benefit and side effects, herb information by Ray Sahelian, M.D. Herbal medicine from the Philippines
Banaba herb has been used in the Philippines for blood sugar control. See diabetes for information on natural supplements and herbs that have an influence on blood sugar, including lipoic acid. One of the active ingredients in banaba leaf is corosolic acid and there has been some research done with it in Japan. I have not come across any human studies, but there has been at least one human study with corosolic acid that showed improvement in blood sugar control in type II diabetics. At this point it is difficult to predict the blood sugar response to a banaba supplement and it is difficult to know what dosage works best, how often to take it, or how it interacts with other supplements used for blood sugar control. We also don't know how this supplement would interact with oral medicines used in diabetes and how it would interact with insulin. If you are a type II diabetic, discuss with your doctor regarding its use to see if this herbal remedy is appropriate for your particular condition.
@ Blood sugar can be reduced by eating less.
Other herbs and nutrients involved in blood sugar control include cinnamon, fenugreek, chromium, and alpha lipoic acid. Extracts from banaba possess activities that both stimulate glucose transport into cells and inhibit adipocyte differentiation.
@Banaba leaf is naturally extracted using only the finest quality leaves. This potent extract provides active levels of corosolic acid, without isolating, fractionizing or using toxic solvents, harsh chemicals or gases.
--Supplement Facts:
Banaba leaf extract 12:1 Lagerstoemia speciosa 250 mg
(Equivalent to 3,000 mg whole leaf) 1.5 % Corosolic Acid = 3.75 mg
--Suggested Use: 1 or 2 banaba leaf extract capsules daily or as directed by a qualified healthcare professional. Since each patient with diabetes is unique, it is difficult to predict the appropriate dosage.
@Side effects, safety
No major banaba herb adverse effects have been reported in medical journals as of 2011.
@Blood sugar and diabetes research studies
The use of banaba for diabetes in the US is still very new and we don't really know the right dosage or how often to take it and also how it interacts with insulin or hypoglycemic medicines. There is no proof yet that taking a banaba supplement with corosolic acid and other compounds will help those who have diabetes, although rodent studies thus far look promising. We also don't know whether long term use will lead to side effects. I am not aware of any studies combining it with metformin or other medicines used in diabetes.
1.Effects of dietary mulberry, Korean red ginseng, and banaba on glucose homeostasis in relation to PPAR-alpha, PPAR-gamma, and LPL mRNA expressions.
Life Sci. 2005.
Mulberry leaf water extract, Korean red ginseng, banaba leaf water extract, and the combination of these herbs fed to mice at the level of 0.5% of the diet significantly increased insulin sensitivity and improved hyperglycemia possibly through regulating PPAR-mediated lipid metabolism.
2.Effects of malted barley extract and banaba extract on blood glucose levels in genetically diabetic mice.
J Med Food. 2004.
This study investigated the therapeutic effects of a malted barley extract (MBE) and of banaba extract on blood glucose, insulin, and other biochemical parameters in genetically diabetic mice. The mice were divided into three groups-control, MBE, and banaba-according to supplementation. Both MBE and banaba extracts were orally administered to the animals for 12 weeks at doses of 62 mg/kg of body weight and 0.8 mg/kg of body weight, respectively. The body and organ (liver and kidney) weights were not different among groups. Fasting blood glucose was significantly lower in the MBE group compared with the control. Hemoglobin A1c content was significantly lower in the MBE group compared with either the control or banaba group. There was no significant difference in the serum insulin level among groups. The glucose-6-phosphatase activity in kidney was significantly lower in both the MBE and banaba groups compared with the control group, but there was no significant difference between the MBE and banaba groups. Therefore, the results of this study demonstrate that MBE alleviates many of the symptoms of diabetes in genetically obese mice and may offer promise as a therapeutic supplement for the normalization of blood glucose levels in humans with hyperglycemia and have beneficial effects in patients with non-insulin-dependent diabetes mellitus.
3. Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study.
J Ethnopharmacol. 2003. Judy WV, Hari SP, Stogsdill WW, Judy JS, Naguib YM, Passwater R.
SIBR, Inc., Bradenton, FL
The antidiabetic activity of an extract from the leaves of Lagerstroemia speciosa standardized to 1% corosolic acid (Glucosol) has been demonstrated in a randomized clinical trial involving Type II diabetics. Subjects received a daily oral dose of Glucosol and blood glucose levels were measured. Glucosol at daily dosages of 32 and 48mg(3.2-4.8gram banaba leaf as 1% crosolic acid) for 2 weeks showed a significant reduction in the blood glucose levels.
4. An extract of Lagerstroemia speciosa L. has insulin-like glucose uptake-stimulatory and adipocyte differentiation-inhibitory activities in 3T3-L1 cells.
J Nutr. 2001.
The effects of extracts isolated from banaba on glucose transport and adipocyte differentiation in 3T3-L1 cells were studied. Our results suggest that banaba extract may be useful for prevention and treatment of hyperglycemia and obesity in type II diabetics.
5. Hypoglycemic effect of extracts from Lagerstroemia speciosa L. banaba leaves in genetically diabetic KK-AY mice.
Biosci Biotechnol Biochem. 1996.
The hypoglycemic effects of Lagerstroemia speciosa L., known by the Tagalog name of banaba in the Phillipines, were studied using hereditary diabetic mice. The mice were fed a test diet containing 5% of the hot-water extract from banaba leaves for a feeding period of 5 weeks. It is suggested that extracts obtained from banaba leaves have beneficial effects on control of the level of plasma glucose in non-insulin dependent diabetes mellitus.
@Kidney health
My kidneys are about half as functional due to diabetes. Would banaba product help me without further damage to kidneys. I do take Byetta plus Novalog plus Lantus. Would it conflict with this
-- Banaba supplement has not been tested in combination with Byetta, Novalog, Lantus, or other medications used for diabetes. We are not aware of any kidney damage that would occur from its use, however very little human research is available with this supplement.
@Liver effect
I want to know can banaba herb be used as a hepatoprotective herb
-- We have not seen any human studies evaluating the effect of banaba herb supplementation on liver enzymes.
@Obesity and weight loss
Antiobesity activity of extracts from Lagerstroemia speciosa L. leaves on female KK-Ay mice.
J Nutr Sci Vitaminol. 1999..
Lagerstroemia speciosa L., has been used as a folk medicine for a long time among diabetics in the Philippines. Extracts from banaba leaves have been reported to reduce diabetic symptoms in genetically diabetic mice. In the present study, female mice of the same strain showing remarkable body weight gain were used to examine the antiobesity effect of dietary banaba extract. Five-week-old female KK-Ay mice were fed a control diet or test diet containing 5% of a hot-water extract from banaba leaves instead of cellulose for 12 weeks. Neither group showed any changes in diet intake during the experimental period. Body weight gain and parametrial adipose tissue weight were lowered significantly in the banaba diet group. Blood glucose levels were not suppressed in the banaba diet group, but hemoglobin A1C was found to be suppressed at the end of the experiment. No effects on the serum lipids were observed, but the mice fed banaba extract showed a significant decrease, to 65% of the control level in total hepatic lipid contents. This decrease was due to a reduction in the accumulation of triglyceride. These results suggest that banaba had a beneficial effect on obese female KK-Ay mice.
@Composition
Valoneaic acid dilactone have been isolated from the leaves as potent alpha-amylase inhibitors.
###Leaves of Tropical Southeast Asian Tree Fight Diabetes
If you're concerned about blood sugar levels, there's a tropical, flowering tree that you need to know about. It grows in the wild forests of Southeast Asia and India. It has big, leathery leaves that have been used by folk healers for many years. And now scientists have found that an extract made from the leaves acts like insulin in your body.
The extract not only helps lower blood glucose, it may prevent weight gain - a common problem for people with a blood sugar imbalance.
A Closer Look at the Leaves
One important study on the effect of the leaves' main active compound on type 2 diabetes was done by Dr. William Judy. The results appeared in the Journal of Ethnopharmacology.
Dr. Judy heads the Southeastern Institute of Biomedical Research (SIBR). It's a research laboratory located in Bradenton, FL. He's a former NASA aerospace scientist. And he taught physiology and biophysics at Indiana University for 15 years. He's an expert in the nervous system and control mechanisms in bioenergetics.
The patients in Dr. Judy's study were given an oral dose of the compound for two weeks. Some took it in a soft gel capsule. Others took it as a powder. Doses were 16mg, 32mg, and 48mg. At the end of the study, all participants had a significant decrease in blood glucose levels. Levels dropped by an average of 30% for those on the soft gel capsules and 20% for those on the powder. And, not surprisingly, the higher the dose, the more effective the compound was.
The compound has also been shown to promote weight loss. In one study, researchers at the Central Research Institute in Shizuoka, Japan worked with a group of mice with type 2 diabetes. A 5% solution of the compound was added to their regular diet. And after 12 weeks, they had a 65% decrease in liver fat.
“This compound is insulin-like and orally deliverable. It has the potential to eventually become a diabetic drug,” said Dr. Xiao Chen, an associate professor at the College of Osteopathic Medicine.
The Natural Tree Remedy
So what's the tree that offers so much promise It's the banaba tree. Lagerstroemia speciosa. The main active component in its leaves is corosolic acid, a natural plant insulin. Corosolic acid is found in other plants, but banaba leaves have three additional active components that enhance its effects. These include:
•Ellagic acid - which helps with glucose absorption.
•Ellagitannins - which activate insulin receptors.
•Valoneaic acid dilactone - which inhibits the enzyme (alpha-amylase) that breaks down starch into sugar.
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