| ###Capsaicin으로 당뇨병 정복 Canadian Scientist Breaks Diabetic Dilemma
-Dr. Dosch 는 당뇨병자의 경우, 1형이든 2형이든 상관없이 췌도주위에 통증성뉴런 숫자가 증대됨을 오랜 경험으로 알고 있었고 당뇨병과 통증성뉴런의 상관성을 확신하고 있던차에, 먼저, 당뇨병 쥐의 췌장에 캡사이신을 주입해 통증성뉴런을 사멸시켜보았다. 그랬더니 캡사이신을 투여한 모든 쥐에게서 인슐린생산이 24시간내에 정상화되는 것을 확인할 수 있었다.
그후 이어서, 당뇨병 쥐들에게 있어서 췌도의 인슐린분비기능의 적절성과 직접 관련있는 (신경에서 분비하는) 뉴로펩타이드 수치를 측정해 보았더니 모든 쥐에게서 저하되어 있음이 확인할 수 있었고, 결국 어떤 이유로든 뉴로펩타이드의 결핍이 인슐린불안정성을 유발하여 그 결과 인슐린저항을 유발하는 것이 아닌가 생각하여, 뉴로펩타이드를 당뇨병쥐의 췌장에 직접 주입했더니, 췌도의 염증이 사라지고, 당뇨병이 소멸되고 인슐린저항이 없어졌음을 확인할 수 있었다. 그의 이론이 맞아들어갔음이 확인된 것이다.
이제, 남은 것은 사람에게서도 동일하게 나타나는가에 있다. 아마도 그러리라고 생각하고 있고 이미, 그 확인 작업에 착수하였다.
또한 당뇨병쥐와 유사한 유전자 부위에 유전적인 결함이 관련되어 있을 것이라는 추정하에 DNA분석작업에도 돌입하였다.
만약 모든 것이 위의 가정대로 맞아 떨어진다면 그들은 단한번의 주사로 당뇨병을 치료할 수 있는 제제를 가지게 될 것이기에 놀라운 일이 아닐 수 없다.
###Capsaicin - Topic Overview
#What is capsaicin
Capsaicin is the ingredient found in different types of hot peppers, such as cayenne peppers, that makes the peppers spicy hot. You can eat it in raw or cooked peppers or as a dried powder, which you can add to food or drinks. It also is available as a dietary supplement and in topical creams that you apply to your skin.
#What is capsaicin used for
When a capsaicin cream or ointment is used on the skin (topical use), capsaicin helps relieve pain. Capsaicin works by first stimulating and then decreasing the intensity of pain signals in the body. Although pain may at first increase, it usually decreases after the first use. Capsaicin stimulates the release of a compound believed to be involved in communicating pain between the nerves in the spinal cord and other parts of the body.
#When you apply it to the skin, capsaicin may help relieve pain from:
Pain disorders, including pain after surgery.
Nervous system problems such as diabetic neuropathy, trigeminal neuralgia, and postherpetic neuralgia (shingles).
Cluster headaches.
Joint problems such as osteoarthritis and rheumatoid arthritis.
Skin conditions such as psoriasis.
Mouth sores due to chemotherapy or radiation.
In general, you use creams containing capsaicin for pain relief. You can put the creams on your skin up to 4 times a day. You may feel a burning or itching sensation the first few times you use the cream, but this will gradually decrease with each use. Wash your hands thoroughly after each use to avoid getting the cream in your eyes or on other moist mucous membranes, where it can cause a burning sensation. Do not use the cream on areas of broken skin.
#Supplement use
When you eat hot peppers or take capsaicin as a dietary supplement, the capsaicin may improve your digestion by increasing the digestive fluids in the stomach and by fighting bacteria that could cause an infection. It may also help fight diarrhea caused by bacterial infection.
Capsaicin may help prevent heart disease. It may stimulate the cardiovascular system and may lower blood cholesterol levels and blood pressure. It also helps prevent clotting and hardening of arteries (atherosclerosis).
Capsaicin acts as an antioxidant, protecting the cells of the body from damage by harmful molecules called free radicals. Capsaicin also may help prevent bacterial infections.
Capsaicin may also make mucus thinner and help move it out of the lungs. It is also thought to strengthen lung tissues and help to prevent or treat emphysema.
#Is capsaicin safe
Experts in the United States generally consider capsaicin to be safe. But it can cause some unpleasant effects, especially for those who are not used to it. Be careful when you cook with or eat hot peppers. Begin with small amounts, and increase the amount as you get used to it.
An allergic reaction to capsaicin is possible. If you are just beginning to use capsaicin, either as fresh or prepared food or in powder form, start with small amounts. If you use a topical cream, you should first apply it to a small area of skin to test for an allergic reaction.
Do not take capsaicin if you have high blood pressure or are already being treated for high blood pressure.
To reduce the burning sensation, remove the seeds from the peppers before you eat or cook with them. Also, if you eat bananas along with the peppers, you may reduce the burning sensation.
Extremely high intake of capsaicin may cause ulcers, but it’s rare for anyone to consume enough for this to be a problem.
Don't let capsaicin come into contact with your eyes and other moist mucous membranes. After you touch capsaicin (or hot peppers), use vinegar or soap to wash your hands so you don't accidentally spread capsaicin to your eyes, nose, or mouth. You can also use disposable gloves to handle hot peppers or to apply capsaicin cream.
Do not apply capsaicin creams to areas of broken skin.
The U.S. Food and Drug Administration (FDA) does not regulate dietary supplements in the same way it regulates medicines. A dietary supplement can be sold with limited or no research on how well it works.
Always tell your doctor if you are using a dietary supplement or if you are thinking about combining a dietary supplement with your conventional medical treatment. It may not be safe to forgo your conventional medical treatment and rely only on a dietary supplement. This is especially important for women who are pregnant or breast-feeding.
When using dietary supplements, keep in mind the following:
Like conventional medicines, dietary supplements may cause side effects, trigger allergic reactions, or interact with prescription and nonprescription medicines or other supplements you might be taking. A side effect or interaction with another medicine or supplement may make other health conditions worse.
The way dietary supplements are manufactured may not be standardized. Because of this, how well they work or any side effects they cause may differ among brands or even within different lots of the same brand. The form of supplement that you buy in health food or grocery stores may not be the same as the form used in research.
Other than for vitamins and minerals, the long-term effects of most dietary supplements are not known.
#Capsaicin health benefits
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Capsaicin is used in topical ointments to help relieve a certain type of pain known as neuralgia. Capsaicin is also used to temporarily help relieve the pain from osteoarthritis or rheumatoid arthritis. Neuralgia is a pain from the nerves near the skin
surface. This pain may occur after an infection with herpes zoster (shingles). It may also occur if you have diabetic neuropathy. Diabetic neuropathy is a condition that occurs in some persons with diabetes. The condition causes tingling and pain in the feet and toes. Capsaicin will help relieve the pain of diabetic neuropathy, but it will not cure diabetic neuropathy or diabetes. Capsaicin works by first stimulating and then decreasing the intensity of pain signals in the body. Substance P is believed to be involved in two processes central to arthritis. By blocking the production and release of substance P, capsaicin can reduce the pain associated with arthritis as well as dampen the transmission of pain messages to the brain.
Capsaicin acts as an antioxidant, protecting the cells of the body from damage by harmful molecules called free radicals. Capsaicin also may help prevent bacterial infections. When peppers are eaten or taken as a dietary supplement, capsaicin may improve digestion by increasing the digestive juice in the stomach and by fighting bacteria that could cause an (such as H.pylori and other) infection. Capsaicin may help prevent heart disease. It may stimulate the cardiovascular system and lower blood cholesterol levels and blood pressure. It also helps prevent clotting and hardening of arteries (atherosclerosis). Capsaicin may also thin mucus and help move it out of the lungs. It is also thought to strengthen lung tissues and help to prevent or treat emphysema.
#Capsaicin, the component that gives jalapeno peppers their heat, may also kill prostate cancer cells, a new study suggests.
"Capsaicin inhibits the growth of human prostate cancer cell in Petri dishes and mice," said lead researcher Dr. H. Phillip Koeffler, director of hematology and oncology at Cedars-Sinai Medical Center and a professor of medicine at the University of California, Los Angeles.
Capsaicin probably has several effects, Koeffler said. Most noticeable is its effect in blocking NF-kappa Beta, a molecular mechanism that promotes cancer cell growth, he noted.
In addition, capsaicin also was effective against leukemia, and might be effective in slowing or preventing the growth of other cancers as well, he added. But it's still too early to reach for the chili sauce, Koeffler said.
Chili, pepper or capsicum also contains minerals like folate, molybdenum, manganese, potassium, thiamin, and copper.
Chili is low in sodium which causes the thickening of blood. The chili enthusiasts should be very pleased to find that chili has a rich endowment of all these antioxidants. Moreover, it is cheap, ready and easily available.
In all researches conducted with chili, capsaicin extract from red chili is used. Capsaicin is a fantastic health stimulant. Many such researches are carried out to ascertain the much desired anti- carcinogenic effects. Here are the findings from one of the many such researches, presented at the annual meeting of the American Association for Cancer Research held at the Anaheim Convention Center in Anaheim, Calif., "Our results demonstrate that :
Capsaicin is a potent anticancer agent, induces apoptosis or programmed cell death in cancer cells and produces no significant damage to normal pancreatic cells, indicating its potential use as a novel chemotherapeutic agent for pancreatic cancer,"
said Dr. Srivastava, Ph.D., lead investigator and assistant professor, department of pharmacology, University of Pittsburgh School of Medicine. Other findings, at the Cedars-Sinai Medical Center in Los Angeles also signal an encouraging result. Accordingly
“Capsaicin had a profound anti-proliferative effect on human prostate cancer cells in culture,"
"It also dramatically slowed the development of prostate tumors formed by those human cell lines grown in mouse models," he said.
These posed as very encouraging news to treatment of cancers. In particular concerns are prostate cancer, the most common cancer among US male gender; and pancreatic cancer, one of the most aggressive cancers with an extremely poor prognosis and low survival rates.
How does chili help in the prevention and slowing down of cancer cell formation
Chili, pepper or capsicum is a very rich source of antioxidants. The antioxidants in our normal diets are vitamin C, vitamin E, polyphenols and carotenoids. Chili contains seven times more vitamin C than orange.
### 10 things you should know about capsaicin -- dec. joint and muscle pain, cholesterol, fat, and cure of RLS
Capsaicin is an ingredient in many topical skin preparations used to relieve pain. Capsaicin is available as a cream, ointment, stick, pad, gel, liquid, or lotion. It is marketed under many brand names including Zostrix, Icy Hot Arthritis Therapy, Capsagel, and Arthricare for Women.
Here, 10 things you should know about capsaicin:
1 - Capsaicin is the active component of chili peppers.
Capsaicin is actually an irritant to humans, producing a burning sensation in any tissue it touches. Capsaicin works by depleting or interfering with substance P, a chemical involved in transmitting pain impulses to the brain. The properties of capsaicin make it an option for relieving pain associated with osteoarthritis, rheumatoid arthritis, and diabetic neuropathy. Capsaicin is used to relieve muscle pain, joint pain, or nerve pain.
2 - Capsaicin is available over the counter.
You do not need a prescription for capsaicin from your doctor. You can find products containing capsaicin in your drugstore for over-the-counter purchase. You should follow the directions given by your doctor or the directions on the label (there are different dosages or strengths of capsaicin available). For pain relief, capsaicin is usually used 3 or 4 times a day. You should rub the capsaicin cream or gel into the painful area until no more cream is visible on the skin.
Wash hands thoroughly after applying capsaicin to other areas of the body. If the capsaicin was applied for hand pain, however, wash your hands after 30 minutes.
3 - Don't use extra doses of capsaicin.
Stick to the directions, but if you should inadvertently miss a dose, use it as soon as you remember -- unless it's close to the time of the next dose.
4 - Capsaicin has no known drug interactions.
Though there are no recognized drug interactions with capsaicin, ask your doctor to be sure that you can use capsaicin, and continue to take your current medications. It's important to inform your doctor about any products you are using.
5 - Capsaicin may cause a burning sensation.
You will likely experience a warm, burning, stinging sensation when you begin using capsaicin. The sensation, which is expected when beginning use, may actually continue for 2 to 4 weeks. The sensation should lessen the longer you use capsaicin. Reducing the number of daily doses of capsaicin will not reduce the sensation, but it may reduce the pain relief achieved.
6 - Arthritis pain relief is not immediate.
Even with regular use of capsaicin, arthritis pain relief will take some time. Pain relief from arthritis typically is evident 1 to 2 weeks after starting capsaicin. To prevent pain from returning, capsaicin must be continued. However, if pain is not better after using capsaicin for 3 or 4 weeks, talk to your doctor. It may not be worth it to continue.
7 - Capsaicin must be handled with care.
Be aware of what can happen if you get capsaicin in your eyes or on other sensitive body parts because of the burning sensation it causes. If capsaicin gets in your eyes, immediately flush your eyes with water. To rid other sensitive areas of capsaicin and the burning feeling, wash the areas with warm soapy water. Keep capsaicin out of reach of children.
8 - Some people should not use capsaicin.
There are warnings about using capsaicin under certain circumstances. Before using capsaicin, tell your doctor about:
•broken skin
•skin irritation
•previous allergic reactions to capsaicin, hot peppers, other drugs, dyes, foods, preservatives
•breastfeeding
•pregnancy or current attempts to become pregnant
Also, be aware that capsaicin should not be used by children under 2 years of age.
9 - Research supports use of capsaicin for osteoarthritis and rheumatoid arthritis.
A study from 1991 involved 70 osteoarthritis patients and 31 rheumatoid arthritis patients. Patients were instructed to apply 0.025% capsaicin or placebo to painful knees, four times a day. Results revealed that 80% of patients treated with capsaicin experienced pain reduction following two weeks of treatment.
10 - Research also supports the use of capsaicin for osteoarthritis of the hands.
Capsaicin 0.075% was evaluated for osteoarthritis and rheumatoid arthritis in a 4-week study, published in 1992. All of the study participants had significant hand pain and applied capsaicin to their hands 4 times daily. It was found that capsaicin reduced tenderness and pain in osteoarthritis of the hand patients, but not rheumatoid arthritis patients when compared to placebo.
###Unlock the Benefits of Cayenne Pepper -By Danica Collins on 08/08/2011
The benefits of cayenne pepper might actually be of greater value to your health as a staple in your medicine cabinet rather than in your spice rack.
The cayenne pepper, or Capiscum annum, derives its proper name from a Greek word meaning “to bite,” a clear allusion to the pungent properties of the plant and its seeds. However, it’s the many medicinal benefits of cayenne pepper that earned it the nickname “The King of Herbs”.
Many people think of this spicy little beauty as just a delicious way to boost the flavor of their cooking, but the health benefits of cayenne pepper is a valuable medical tool with a wide range of uses.
@According to a combination of herbal lore and medical research, cayenne pepper benefits may:
•Ease congestion
•Aid in weight reduction
•Prevent tooth decay
•Support digestion
•Heal ulcers
•Stop hemorrhaging
•Relieve infection
•Cure arthritis
•Numb pain
•Clean the blood
•Regulate blood pressure
•Lower cholesterol
•Nourish the heart
Part of the logic behind the many herbal applications of capsicum is that it is a catalyst, and can be used to enhance the effects of other treatments. Little is known about the pharmacological activities of capsicum in humans, but it is abundantly clear that capsicum is a stimulant. In fact, it has been called “the purest and most certain stimulant in the herbal materia medica.”
The Dispensatory of the United States of America, 23 ed., 1943, states that, “Capsicum is a powerful local stimulant, producing, when swallowed, a sense of heat in the stomach, and a general glow over the body without narcotic effect.”
Chili peppers have long reigned over the canon of folk medicine. Archeological remains show that capsicum was a dietary staple in Mexico 9,000 years ago. In Indonesia, capsicum is used as a traditional remedy for gonorrhea. In central Africa, it’s used as a calming, stress-relieving tonic. In Hawaii, it’s used for backaches, rheumatism, and swollen feet.
@Cayenne Pepper Health Benefits: Treating Heart Conditions
Some reports even suggest that capsicum, one of the benefits of cayenne pepper can prevent heart attacks. One study published in the Journal of Agricultural and Food Chemistry in 1979 found that capsicum contained the most natural vitamin E — often used to treat heart conditions — of all the edible plants analyzed by the research team.
In a fresh, ripe pepper, the researchers measured 3-10mg/.100gs, meaning capsicum can be considered a significant dietary source of vitamin E.
Additionally, the form of vitamin E found in capsicum is an especially stable one, which makes it particularly well-suited for medical applications.
Recently, capsicum research has been centered on the pepper’s potential viability as a cancer treatment. According to the American Association for Cancer Research, capsaicin (the same component of the cayenne that makes the peppers so peppery) causes cancer cells to commit apoptosis. In plain language, that means that capsaicin causes cancer cells to kill themselves.
This claim comes from a study done by a team of researchers from the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, along with colleagues from UCLA. The researchers discovered that the capsaicin component of the cayenne pepper caused human prostate cells to undergo programmed cell death.
As exciting as these results are, the Association has been careful to emphasize that more studies need to be done before it’s clear how capsaicin can be used in treating humans.
The benefits of cayenne pepper range from cancer to our daily health needs. Another promising line of research is the use of capsicum as an important aid to weight reduction. Studies done over the last 30 years indicate that capsicum has enormous potential for promoting fat loss.
A study in the American Journal of Clinical Nutrition stated that capsicum has been successfully used to increase the loss of abdominal fat for overweight or obese individuals.
Other studies indicate that capsicum can help those looking to shed pounds by:
•Normalizing insulin and glucose levels
•Boosting energy
•Increasing metabolic speed
•Suppressing hunger
•Promoting satiety (the feeling of fullness)
Those last 2 items — suppressing hunger and promoting satiety — can be strengthened if you also consume green tea regularly as a part of your weight management strategy.
There are just as many good ways to work capsicum into your diet as there are good reasons. If you like spice, go for the peppers themselves — the options for using peppers in cooking are endless! If your mouth can’t take the heat, there are a number of good quality supplements available that won’t leave your tongue tingling.
Related articles of interest:
17 Health Benefits of Cayenne Pepper
11 Foods That Speed Up Your Metabolism
Make a Date with Chili Pepper
Ten Top Common Healing Herbs and Spices
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