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@@@B-Vitamin ÃæºÐµµ :Bcomp, Biotin, lipoicAcid,coQ10


1. Pyruvate
-- ƯÈ÷ B1  B5 °áÇ̽Ã, *Pyruvate+ lacate(#13 below) : lipoic acid °áÇ̽ûç.
*Lipoic acid : ³ëÈ­°ü·ÃÁúȯÀÇ ¿øÀÎ. DMÄ¡·á ¹× °£Çص¶¿¡ ¹Ýµå½Ã ÇÊ¿ä.


2, 3, 4, 5. a-Ketoglutarate, a-Ketoisovalerate, a-Ketoisocaproate, and a-Keto-©¬-methylvalerate
: B1, B2, B3, B5 and lipoic acid (esp. B1 B5) °áÇÌ °ü·Ã
-- ½Å°æ±â´É°ú ¼Ò³â±â ¼ºÀå°ú ÇнÀ¹ß´Þ¿¡ Áß¿ä : °áÇ̽à memory loss, anemia, and dermatitis À¯¹ßµÊ.


6. Xanthurenate
-- (¸ðµç ´Ü¹éÁú ´ë»ç¿¡ ¹Ýµå½Ã ÇÊ¿äÇÑ)B6 °áÇÌ °ü·Ã,
-- ÇÇÀÓÁ¦, Ç×°íÇ÷¾Ð¾àÁ¦, ±â°üÁöÈ®ÀåÁ¦ º¹¿ë½Ã, ´ã¹è¿¬±â-»ìÃæÁ¦-Á¦ÃÊÁ¦ ³ëÃâ½Ã »ó½Â
-- ±ÕÇüÀå¾Ö, ÇÇ·Î, ±â¾ï/Á¤¼­ºÒ¾ÈÁ¤(PMS and ADHD) ÀÚÆóÁõ Áõ»ó À¯¹ß
-- Ç÷´çÁ¶ÀýÀå¾Ö ¹× DM°ú °ü·ÃµÊ


7. ©¬-Hydroxyisovalerate
--biotin °áÇÌ °ü·Ã.
--ÀÓ½Å, Ç×»ýÁ¦³ª Ç×Àü°£Á¦ »ç¿ë°ú °ü·ÃµÊ.
--Å»¸ð, ÇǺιßÁø, ÇǺο°, ¸é¿ª°áÇÌÁúȯ, ±ÙÀ°¾àÈ­¿Í °ü·ÃµÊ


8. Methylmalonate
--vitamin B12 °áÇÌ °ü·Ã
--½Å°æ±â´ÉÀÌ»ó, ºóÇ÷°ú ÇÇ·ÎÁõ»ó À¯¹ß.
--½ÉÇ÷°ü°è Áúȯ À¯¹ß °¡´É,  homocysteine »ó½Â, Achlorhydria¸¦ À¯¹ß.


9. Formiminoglutamate (FIGLU)
--folic acid °áÇÌ°ü·Ã,
--¼Ò³â±â ¹ß´Þ¹®Á¦ À¯¹ß ¿ì¿ïÁõ, ¸é¿ª±â´É ÀÌ»ó, ½ÉÇ÷°üÁúȯ À¯¹ß


@@@¹ÌÅäÄܵ帮¾ÆÀÇ ¼¼Æ÷¿¡³ÊÁö»ý»ê ´É·Â : Carnitine, B2, coQ10,Cr,V,Aa


10, 11, 12. Adipate, Suberate, and Ethylmalonate
--Carnitine/B2(mitochondrial fatty acid utilization) °áÇÌ°ü·Ã
*B2 °áÇÌ-- ź¼öÈ­¹° ´ë»çÀå¾Ö, ÆíµÎÅë, Ä¡¸Å À¯¹ß.
*Carnitine ºÎÁ· --Alzheimer¡¯s, ³ëÈ­°ü·Ã ÀÎÁö±â´É-½É±â´É ÀúÇÏ¿Í °ü·Ã


13. Lactate : ºñŸ¹Î B1 Á¸Àç½Ã °£³» Cori ȸ·Î¿¡¼­ ÇÇ·çºê»êÀ̳ª Æ÷µµ´çÀ¸·Î ÀüȯµÊ
-Low lactate : À°Ã¼È°µ¿ ÀúÇϽà ¶Ç´Â À°Ã¼È°µ¿ÀÌ ±Ø½ÉÇÑ ¿îµ¿¼±¼ö.
-High lactate : ±ÙÀ°ÀÇ °æ·Ã, ÇÇ·Î , ¸Ó¸® ¼ÓÀÌ ¾È°³ ³¤ µíÇÑ ´À³¦ -- coenzyme Q10 (CoQ10)ºÎÁ·°ú °ü·ÃµÊ,
 :  °íÇ÷¾Ð, ½ÉÁúȯ, ¾Ï°ú °ü·Ã


14. ©¬-Hydroxybutyrate
-- ketosis ¹ß»ý. ´çÀÌ¿ë´ë»ç ÀÌ»ó ¹ß»ý½Ã Áö¹æ»ê´ë»ç °æ·Î È°¼ºÈ­·Î À¯¹ß (INS chromium, vanadium, lipoic acid Åõ¿©·Î °³¼±µÊ.)


15, 16, 17. Succinate(ÁÖ¼®»ê), Fumarate(È£¹Ú»ê), and Malate(¸»»ê)-- Citric Acid CycleÀÇ ±¸¼º¼ººÐ.
-Higher levels : energy production °úÁ¤¿¡ ÀÌ»ó ¹ß»ý.
-Low levels : amino acid °ø±Þ ºÒÃæºÐ.
* a-ketoglutarate ºÎÁ· +succinate, malate, and fumarate ºÎÁ·ÀÌ °ãÄ¥ ¶§´Â : CoQ10 °ø±ÞÇØ ÁÖ¾î¾ß ÇÔ,


18. Hydroxymethylglutarate (HMG)
-- CoQ10 »ýÇÕ¼º °úÁ¤ ÀÌ»ó ½Ã»ç : ÄÝ·¹½ºÅ×·ÑÀúÇÏÁ¦ÀÎ ½ºÅ¸Æ¾ÀÌ HMGCoARÀ» °æÀ¯ÇÏ¿© CoQ10À» »ýÇÕ¼ºÇÏ´Â ÀÌ°úÁ¤À» Â÷´ÜÇÔ, CoQ10À» µû·Î °ø±ÞÇÒ ÇÊ¿ä°¡ ÀÖÀ½


@@@½Å°æ±â´É-- ½Å°æÀü´Þ¹°Áú °ü·Ã : Tyr/DLPA, Trp. MgB6
ù 3 Ç׸ñÀÌ ³ôµç ³·µç ¸Å¿ì Áß¿äÇÑ Àǹ̸¦ °¡Áü -- symptoms of mental, emotional, and behavioral problems.


19, 20. Vanilmandelate (VMA) & Homovanillate (HVA)
: neurotransmitters ¿¡Çdz×ÇÁ¸°/³ë¸£¿¡Çdz×ÇÁ¸°ÀÇ ºÐÇػ깰·Î hormone and nerve impulse transmission¿¡ °ü¿©.
-- Low : ¿ì¿ïÁõ, ¼ö¸éÀå¾Ö, ½ºÆ®·¹½ºÃ³¸® °ï¶õ, ÇÇ·Î --digestives +tyrosine or phenylalanine ÀÌ ÇÊ¿ä,
-- High : ½Å°æÀü´Þ¹°Áú °ú´ÙÈ°¼º, ½ºÆ®·¹½º °ü·Ã – both internal (e.g., mental/emotional) and external (e.g. toxins).


21. 5-Hydroxyindolacetate (5-HIA)
: serotonin ºÐÇØ »ê¹°.
: Low - º¯ºñ, ¿ì¿ï, ÇÇ·Î, ¼ö¸éÀå¾Ö, ÁÖÀǷ°áÇÌ/ÇൿÀå¾Ö À¯¹ß
: High - Ç׿ïÁ¦ »ç¿ë°ú °ü·Ã, L-tryptophan ºÎÁ·½Ã, °íÆ®¸³ÅäÆÇ ÇÔÀ¯½ÄÀÌ + À§»êºÐºñÁ¤»óÈ­Á¦Á¦/pancreatic enzymes ÇÊ¿ä


22. Kynurenate : quinolinate (see #23) µ¶¼ºÈ¿°ú¸¦ ÁÙ¿©ÁÜ.
- Elevations : vitamin B6 ºÎÁ·°ú °ü·Ã, ÀÌ ¶§ ƯÈ÷ ´õºÒ¾î xanthurenate (see #6)°¡ ³ô¾ÆÁü


23. Quinolinate
--elevations : (ƯÈ÷ ¹ÙÀÌ·¯½º)°¨¿°Áõ µîÀ¸·Î ¸é¿ª°è°¡ ÀÚ±ØµÇ¾î ³ªÅ¸³ª´Â ¿°Áõ°úÁ¤ ½Ã»ç.
-- High quinolinate levels in the brain : ¼ö¸éÀå¾Ö, °ú¹Î¹ÝÀÀ, ½Å°æÁúÀû¹ÝÀÀ : ¿øÀÎÁ¦°Å+ Ç׿°ÁõÄ¡·á+ Mg Åõ¿©


@@@°£ Çص¶±â´É : Aa/Arg-GlyB5-AspGluB5-NAC/Met/MSM
- °£Çص¶°úÁ¤ ÀÌ»ó½Ã¿£ ¶ò/¸Û/¾È°³³¤ ´À³¦, µÎÅë, ºÒ¸é, È­Çйΰ¨¼º, ±×¿Ü ´Ù¾çÇÑ ¸¸¼ºÀûÀÎ °Ç°­ÀÌ»ó À¯¹ß.


24, 25, 26. Citrate, cis-Aconitate, and Isocitrate
:  energy production and removal of toxic ammonia¿¡ ¾çÂÊÀ¸·Î °ü°è.
- High levels : ammonia toxicity ½Ã»ç.
- Low : Chronic loss·Î ÀÎÇÑ arginine deficiency.


27. 2-Methylhippurate :: xylene Á¦µ¶°úÁ¤ÀÇ Áß°£´ë»ç¹°Áú.
-Elevations : exposure to paint, varnishes, paint thinners, solvents, and many aerosols.( liver toxicity)
 : XyleneÁ¦µ¶À§ÇØ glycine + vitamin B5 °¡ Ãß°¡·Î ÇÊ¿ä


28. Orotate : °£¿¡¼­ ¾Ï¸ð´Ï¾Æ¸¦ ¹«µ¶ÇÑ ¿ä¼Ò·Î Àüȯ, ArgÀ» Ãß°¡Çϸé Àüȯ·ÂÀÌ ´õ °­È­µÊ
--a-ketoglutarate, magnesium, aspartic acid, and glutamic acid¸¦ ÁÖ¸é ¾Ï¸ð´Ï¾Æ µ¶¼ºÀÌ ´õ ¾àÈ­µÇ°í.
--»ó½Â½Ã : ¾Ï¸ð´Ï¾Æ·Î ÀÎÇØ ³ú±â´É ÀÌ»ó ¹ß»ý-»ç°í´É·ÂÀúÇÏ, ÇÇ·Î, µÎÅë, À½½Ä¹°°ú¹Î¼º ¹ß»ý


29. Glucarate : »ìÃæÁ¦, ó¹æ¾àÁ¦, À½½Ä¹° ±¸¼º¼ººÐ, Àå³»¼¼±Õµ¶¼ÒµîÀ» Á¦µ¶ÇÏ´Â ÀÛ¿ë
--High levels : glycine, glutathione, n-acetylcysteine,  liver-specifc antioxidants µîÀÌ ÇÊ¿ä


30. a-Hydroxybutyrate
: glutathioneÀ» Ãß°¡·Î ´õ »ý»êÇÏ¿© ´ë»ç½ºÆ®·¹½º¸¦ ÇØ°áÇÏ°íÀÚ ÇÒ ¶§ »ó½Â.
- Elevated : glutathione. sulfur amino acids and glutathioneÀÌ ÇÊ¿äÇÔÀ» ½Ã»ç


31. Pyroglutamate : ±Û·çŸ¹Î »ý¼º°úÁ¤ÀÌ È°¼ºÈ­ µÉ¶§ ÀÌ¿ë
: elevation -- glutathione »ç¿ëÀÌ ¿Õ¼ºÇÏ¿© ¾Æ¹Ì³ë»êÀÌ »ó´ëÀûÀ¸·Î ºÎÁ·ÇÔÀ» ½Ã»ç - methionine and glycine¸¦ ´õ °ø±ÞÇ϶ó.


##º´ÀÇ È¸º¹¼Óµµ¿Í °ü·ÃµÈ ºÎ±³°¨½Å°æ°èÀÇ ÀÚ±Ø(°¨ÃÊ, ±Û·çŸ¹Î) http://blog.daum.net/shchang425/16638633

´ÙÀ½±Û : Çö󺸳ëÀ̵å
ÀÌÀü±Û : RSDS-CRPS 3rd