Á¦  ¸ñ :   X-factor : vitamin K2

###Subtypes of vitamin K2(=X-factor, menaquinone) --protector for HCC, prostCa

***MK-4 45mg MK-7 45mcg daily
Vitamin K2 (menaquinone), is itself a category of vitamin K that includes many types of vitamin K2. The two subtypes of vitamin K2 that have been most studied are menaquinone-4 (menatetrenone, MK4) and menaquinone-7 (MK7).

 

MK4 (ÃéÀå °íȯ µ¿¸Æº®¿¡¼­ ºñŸ¹ÎK1À¸·ÎºÎÅÍ ÀüȯµÊ, °ñ´Ù°øÁõ ¹× °ñÀý¿¹¹æ¿¡ °ü¿© : ÇÏ·ç45mgÃßõ) is produced via conversion of vitamin K1 in the body, in the testes, pancreas and arterial walls.[3] While major questions still surround the biochemical pathway for the transformation of vitamin K1 to MK4, studies demonstrate that the conversion is not dependent on gut bacteria, occurring in germ-free rats[4][5] and in parenterally-administered K1 in rats.[6][7] In fact, tissues that accumulate high amounts of MK4 have a remarkable capacity to convert up to 90% of the available K1 into MK4.[8][9]

In contrast to MK4, menaquinone-7 (MK7) is not produced by humans but is converted from phylloquinone in the intestines by gut bacteria.[10] However, bacteria-derived menaquinones (MK7) appear to contribute minimally to overall vitamin K status.[11][12] MK4 and MK7 are both found in the United States in dietary supplements for bone health.

 

The US FDA has not approved any form of vitamin K for the prevention or treatment of osteoporosis; however, MK4 has been shown to decrease fractures up to 87%.[13] In the amount of 45 mg daily MK4 has been approved by the Ministry of Health in Japan since 1995 for the prevention and treatment of osteoporosis.[14]

 

Vitamin K2 (MK4, but not MK7 or vitamin K1) has also been shown to prevent bone loss and/or fractures in the following circumstances:

caused by corticosteroids (e.g., prednisone, dexamethasone, prednisolone),

anorexia nervosa,[19]
cirrhosis of the liver,[20]
postmenopausal osteoporosis,[21][22][23][24][25][26]
disuse from stroke,[27]
Alzheimer¡¯s disease,[28]
Parkinson disease,[29]
primary biliary cirrhosis[30]
and leuprolide treatment (for prostate cancer).[31]

 

Vitamin K and bone health

There is physiological and observational evidence that vitamin K plays a role in bone growth and the maintenance of bone density, but efforts to delay the onset of osteoporosis by vitamin K supplementation have proven ineffective.

 

Vitamin K takes part in the post translational modification as a cofactor in ¥ã-carboxylation of vitamin K dependant proteins (VKDPs). VKDPs have glutamate residues (Glu). Biophysical studies have suggested that supplemental vitamin K promotes osteotrophic processes and slows osteoclastic processes via calcium bonding. Study of Atkins et al.[81] revealed that phylloquinone, menatetrenone (MK4) and menadione promote in vitro mineralisaton by human primary osteoblasts. Other studies have shown that vitamin K antagonists (usually a class of anticoagulants) lead to early calcification of the epiphysis and epiphysial line in mice and other animals, causing seriously decreased bone growth. This is due to defects in osteocalcin and matrix Gla protein. Their primary function is to prevent overcalcification of the bone and cartilage. Vitamin K is important in the process of carboxylating glutamic acid (Glu) in these proteins to gamma-carboxyglutamic acid (Gla), which is necessary for their function.[82][83] Vitamin D is reported to regulate the OC transcription by osteoblast thereby showing that vitamin K and vitamin D work in tandem for the bone metabolism and development. Lian and his group discovered two nucleotide substitution regions which they named "osteocalcin box" in the rat and human osteocalcin genes.[84] They found a region 600 nucleotides immediately upstream from the transcription start site that support a 10-fold stimulated transcription of the gene by 1,25-dihydroxy vitamin D.

 

[edit] Vitamin K1 and bone health

Data from the 1998 Nurses Health Study, an observational study, indicated an inverse relationship between dietary vitamin K1 and the risk of hip fracture. After being given 110 micrograms/day of vitamin K, women who consumed lettuce one or more times per day had a significantly lower risk of hip fracture than women who consumed lettuce one or fewer times per week. In addition to this, high intakes of vitamin D but low intakes of vitamin K were suggested to pose an increased risk of hip fracture.[83][85] The Framingham Heart Study[86] is another study that showed the similar result. Subjects in the highest quartile of vitamin K1 intake (median K1 intake of 254 ¥ìg/ day) has 35% lower risk of hip fracture than those in the lowest quartile. Comparing with the daily recommended intake (DRI) of 90 and 120 ¥ìg/ day, both the above intakes are higher than existing DRI.

 

In the face of this evidence, a large multicentre randomized placebo-controlled trial was performed to test the supplementation of vitamin K in post-menopausal women with osteopenia. Despite heavy doses of vitamin K1, no differences were found in bone density between the supplemented and placebo groups.[87]

 

[edit] Vitamin K2 (MK4) and bone health

In contrast, MK4 has been shown in numerous studies to reduce fracture risk, stop and reverse bone loss. In Japan, MK4 in the dose of 45 mg daily is recognized as a treatment for osteoporosis.[85][88] MK4 has been shown to decrease fractures up to 87%.[13] In the amount of 45 mg daily MK4 has been approved by the Ministry of Health in Japan since 1995 for the prevention and treatment of osteoporosis.[14]

 

[edit] Vitamin K2 (MK7) and bone health

Menaquinone-7 (MK7), which is abundant in fermented soybeans (natto), has been demonstrated to stimulate osteoblastic bone formation and to inhibit osteoclastic bone resorption.[89] In another study, use of MK-7 caused significant elevations of serum Y-carboxylated osteocalcin concentration, a biomarker of bone formation. MK-7 also completely inhibited a decrease in the calcium content of bone tissue by inhibiting the bone-resorbing factors parathyroid hormone and prostaglandin E2.[90] On 19 February 2011, HSA (Singapore) approved a health supplement which contains vitamin K2 (MK7) and vitamin D3 for increasing bone mineral density.[91]

 

[edit] Vitamin K and Alzheimer's disease

Research into the antioxidant properties of vitamin K indicates that the concentration of vitamin K is lower in the circulation of carriers of the APOE4 gene, and recent studies have shown its ability to inhibit nerve cell death due to oxidative stress. It has been hypothesized that vitamin K may reduce neuronal damage and that supplementation may hold benefits to treating Alzheimer's disease, although more research is necessary in this area.[92]

 

[edit] Vitamin K used topically

Vitamin K may be applied topically, typically as a 5% cream, to diminish postoperative bruising from cosmetic surgery and injections, broken capillaries (spider veins), to treat rosacea and to aid in the fading of hyperpigmentation and dark under-eye circles.[citation needed]

 

[edit] Vitamin K and cancer

While researchers in Japan were studying the role of vitamin K2 as the menaqunone-4 (MK-4) form in the prevention of bone loss in females with liver disease, they discovered another possible effect. This two year study which involved 21 women with viral liver cirrhosis found that women in the supplement group were 90 percent less likely to develop liver cancer.[93][94] A German study performed on men with prostate cancer found a significant inverse relationship between vitamin K2 consumption and advanced prostate cancer.[95]


 

###The X Factor of Weston A. Price

 

IMPORTANT UPDATE, SPRING 2007: Price's "X Factor" or "Activator X" is now believed to be the fat-soluble vitamin K2. Please follow the link to read Chris Masterjohn's article on the Weston A. Price Foundation site to learn how this sixty-year-old mystery was finally solved!

 

Dr. Weston A. Price, a Cleveland dentist, has been called the "Charles Darwin of Nutrition." In his search for the causes of dental decay and physical degeneration that he observed in his dental practice, he turned from test tubes and microscopes to the evidence supplied by human beings. Dr. Price sought the factors responsible for fine teeth among the people who had them —the isolated "primitives." The world became his laboratory. As he traveled, his findings led him to the belief that dental caries and deformed dental arches resulting in crowded, crooked teeth and unattractive appearance were a sign of physical degeneration, resulting from what he had suspected —nutritional deficiencies.

 

Price travelled the world over in order to study isolated human groups, including sequestered villages in Switzerland, Gaelic communities in the Outer Hebrides, Eskimos and Indians of North America, Melanesian and Polynesian South Sea Islanders, African tribes, Australian Aborigines, New Zealand Maori and the Indians of South America. Wherever he went, Dr. Price found that beautiful straight teeth, freedom from decay, stalwart bodies, resistance to disease and fine characters were typical of primitives on their traditional diets, rich in essential food factors.

 

When Dr. Price analyzed the foods used by isolated primitive peoples he found that they provided at least four times the water soluble vitamins, calcium and other minerals, and at least TEN times the fat soluble vitamins —vitamin A and vitamin D —from animal foods such as fish eggs, shellfish, organ meats and butter from cows eating green grass.

 

Dr. Price discovered an additional fat soluble vitamin that he called "Activator X" and which was also referred to by others as the Price Factor or X Factor, and is now believed to be vitamin K2. It is a powerful catalyst which, like vitamins A and D, helps the body absorb and utilize minerals. It was present in the diets of all the healthy population groups he studied but unfortunately has almost completely disappeared from the modern western diet. Sources include organ meats from cows eating green grass, fish eggs and shellfish. Butter can be an especially rich source of Activator X/vitamin K2 when it comes from cows eating rapidly growing grass in the Spring and Fall seasons. It disappears in cows fed cottonseed meal or high protein soy-based feeds. Fortunately, Activator X/vitamin K2 is not destroyed by pasteurization.

 

The importance of good nutrition for mothers during pregnancy has long been recognized, but Dr. Price's investigation showed that primitives understood and practiced preconception nutritional programs for BOTH parents. Many tribes required a period of premarital nutrition, and children were spaced to permit the mother to maintain her full health and strength, thus assuring physical excellence to subsequent offspring. Special foods were often given to pregnant and lactating women, as well as to the maturing boys and girls, in preparation for future parenthood. Dr. Price found these foods to be very rich in fat soluble vitamins A, vitamin D and Activator X —nutrients found only in animal fats.

 

These primitives with their fine bodies, homogeneous reproduction, emotional stability and freedom from degenerative ills stand forth in sharp contrast to those subsisting on the impoverished foods of civilization —sugar, white flour, pasteurized lowfat milk and convenience foods filled with extenders and additives.

 

The discoveries and conclusion of Dr. Price are presented in his classic volume Nutrition and Physical Degeneration. The book contains striking photographs of handsome, healthy primitives and illustrates in an unforgettable way the physical degeneration that occurs when human groups abandon nourishing traditional diets in favor of modern convenience foods.

 

###Why Our Ancient Ancestors Never Got Cancer

 

Doctor Discovers ¡°X-Factor¡± That Protected Them From Cancer, Heart Attacks, Alzheimer¡¯s and MORE...

 

Now YOU Can Use The Power of This ¡°X-Factor¡± To:
 
Clear Your Clogged Arteries
 Keep Your Bones Stronger than Steel
 Seek and Destroy Cancer Cells
 Shield Your Brain from Alzheimer¡¯s  


Dear Friend,
It could have been a scene out of an Indiana Jones movie...
An American doctor traveling the world during the 1930s, living with Native cultures to find the cause of the decay and disease he saw in his patients uncovered what may be the most important discovery of our time.


You see, when this doctor analyzed the diets of Native people, he discovered what he called an ¡°X-Factor¡± that gave Native people remarkable qualities you and I would envy.
Concentrated in organ meat, this X-Factor produces perfect teeth... broad, beautiful smiles... happy-go-lucky personalities... great physical strength... strong, fat-free bodies and more importantly NO DISEASE.


Chronic diseases like cancer, heart disease, obesity, bone loss and Alzheimer¡¯s were UNKNOWN in Native cultures who had high levels of this X-Factor.


But when these Native people switched to a Western diet and stopped eating organ meat, they quickly fell sick with disease.


But there¡¯s good news.


New studies finally solved the mystery of the elusive X-Factor.

 

For the first time, we know EXACTLY what the X-Factor is and how to get more of it.  


And unlike our Native ancestors, you DON¡¯T have to eat organ meat or hunt for your food to get the X-Factor¡¯s power to cure and prevent disease.

 

In the next 5 minutes, as you read to the end of this letter, you¡¯ll discover why you must grab the earliest opportunity to find out about this mystery - before it's banned and how clinical studies published in peer-reviewed medical journals prove the X-Factor¡¯s amazing ability to:


•Scrub your arteries clear of the dangerous plaque that clog your blood vessels and lead to heart attack.
•Strengthen your bones and slash your risk of osteoporosis.
•Kill specific kinds of cancer cells without harming the healthy cells around them.
•Protect your brain from senility, dementia and Alzheimer¡¯s.
•Reduce inflammation and fight arthritis.
•Normalize your blood sugar and protect against diabetes.
•¡°Activate¡± the critical vitamins A and D, making them stronger and more effective.

 

Discover the True Identity of the X-Factor...While You Still Can

 

If you or someone you care about is suffering from, or at risk of getting a chronic disease, this may be the most important letter you¡¯ll ever read.

You¡¯ll discover exactly how YOU can use this X-Factor to prevent -- and in some cases reverse -- diseases like cancer, heart disease, Alzheimer¡¯s and bone loss.


You¡¯ll also find out why this breakthrough has been hushed up in the media and how you can discover the X-Factor¡¯s true identity before mainstream medicine and the big drug companies bury this secret forever. 


The X-Factor is something that NEEDS to be part of our daily routine. It was in the past, back when we lived on this planet disease free.


It can be again.


Do this one thing, and you¡¯ll take the tragedy of chronic disease OUT of your life and the lives of the people you care about.


But first, here¡¯s why doctors in-the-know who already use the X-Factor to prevent and reverse disease are saying...
¡°It¡¯s Just a Matter of Time Before The X-Factor Becomes the Next World-Wide Phenomenon...¡±

 

When Dr. Weston Price left his Ohio dental practice in the 1930s to explore Native cultures like a real-life Indiana Jones, he never imagined he would make a discovery that could help YOU live younger, longer... and possibly disease free.


By analyzing the diets of Native people, Dr. Price discovered what he called an ¡°X-Factor¡± that activates or ¡°switches on¡± vitamins A and D, making them stronger and more effective.

 

He also found that the X-Factor binds to the minerals from your food, making them easier for your body to use and absorb.

As a dentist, he first noticed the X-Factor¡¯s influence on bones and teeth. In his now famous case studies, he photographed Native people before and after they started eating Western, American diets.


In just a single generation, they went from being strong and vital to being born with bone deformities and crooked teeth full of cavities.


Not only did they lose their perfect teeth and wide smiles, they became victims of diseases like cancer, heart disease and bone loss.


In one of Dr. Price¡¯s groundbreaking studies, he showed that rats given the X-Factor were cured of rickets, a bone disease common in children with vitamin deficiencies.

During his field work, Dr. Price was able to cure children of bone and heart diseases, even mental disorders like extreme anxiety... all with the X-Factor.

 

Over time, Dr. Price came to realize that... Natives with the highest levels of the X-Factor had the strongest, leanest and most attractive bodies and lived WITHOUT disease.

 

Doctor Approved: Leading MDs and Health Care Professionals Praise The X-Factor Revolution
¡°The X-Factor has the potential to become the next phenomenon in health...¡±
¡°The X-Factor has the potential to become the next phenomenon in health.  The current studies are strong and if that trend continues, this could be the answer many have been searching for.
I strongly recommend you read the information revealed here, talk to your doctor and apply it in your own life.¡±
 -- Dr. Tim Reynolds, MD, FACEP

¡°Plays a vital role in maintaining healthy bones and arteries...¡±
¡°Recent research has revealed that [the X-Factor] plays a vital role in maintaining healthy bones and arteries by keeping calcium in the bones and out of the arteries.¡±
-- Dr. William Davis, MD

¡°Has the potential to prevent or even reverse some forms of heart disease...¡±
¡°Researchers have confirmed [the X-Factor's] profoundly positive impact on human health. It has been shown in numerous studies to actually extract calcium from the blood and arteries and then ¡®amazingly¡¯ deposit this calcium into growing or aging bones.
It appears to have the potential to prevent or even reverse some forms of heart disease and, at the same time, to do the same for bone loss, without the side effects that sometimes accompany the use of pharmaceuticals to treat these ailments.
It's also more effective than vitamin E in terms of its ability to ¡®mop up¡¯ the free radicals that damage cell membranes.¡±
-- Dr. Anthony G. Payne, Ph.D.

¡°Why don¡¯t they teach this to health care providers?¡±
¡°I¡¯ve been in the health care profession for years and I NEVER knew this research was out there. It¡¯s unfortunate that more people don¡¯t know about this. The X-Factor should be included in the curriculum for all health care providers.

 The research is solid and the book presents everything in a clear and concise manner.
The X-Factor Revolution makes it easy for ANYONE to get the disease-fighting benefits. After learning about X Factor, I am going to apply it to my own life and educate my patients about this revolutionary idea.¡±

---Cassie Bateman, ARNP, FNP-BC
You won¡¯t read about this in the history books, but many Native Americans who lived back in the old days enjoyed a kind of power and vigor that is hard for us to understand or believe.

Back in the 16th century, Cabeza de Vaca was one of the first Europeans to explore what is now Texas and the Southwest, and he lived with the Native Americans for eight years.1

During his time with the Indians, De Vaca witnessed amazing feats of strength and endurance.

 

Check out these excerpts from his journal:
¡°One Native American ran down a buffalo on foot and killed it with his knife as he ran by its side.¡±2
¡°Traversed by an arrow, he does not die but recovers from his wound¡¦ the men were happy, generous, with amazing physical prowess¡¦ they go naked in the most burning sun, in winter they go out in early dawn to take a bath, breaking the ice with their body.¡±

 

To our modern ears it sounds like these Native Americans were supermen. In reality, their power came from the ¡°X-Factor¡± found in the organ meats and butter fat they ate on a regular basis.

 

When Dr. Price first wrote about the X-Factor in the 1940s, he had limited resources and the X-Factor remained a secret for another 60 years.

 

It wasn¡¯t until new research published in the last 5 to 10 years revealed its true identity.
Today, we know the X-Factor to be a kind of ¡°missing link¡± that may change our modern lives forever.


In this letter, I¡¯ll show you the clinical evidence that backs up Dr. Price¡¯s research and proves that it¡¯s possible for YOU to live a strong, vibrant and disease-free life. 

I¡¯ll show you how the X-Factor effortlessly builds bones of steel, clears your arteries of heart attack-causing plaque, and shields your brain from the devastating effects of Alzheimer¡¯s.


And you don¡¯t have to live in the jungle, hunt wild animals or eat organ meat.


Even I Was Skeptical At First...


My name is Jason Kennedy.  
I¡¯m a health writer, researcher and editor. I ghostwrite books, articles and newsletters for the leading anti-aging doctors in the United States.


I¡¯ve trained under some of the leading medical doctors, healers and innovators in the alternative health field. And it was one of these doctors that introduced me to the work of Dr. Price and his influence on modern disease prevention.

I¡¯ve been in this business for a long time and I don¡¯t believe that any one nutrient or supplement can ¡°cure¡± all your problems... and I¡¯m always skeptical of anything that claims to be a ¡°health breakthrough.¡±


But having followed the X-Factor story for years, I am truly amazed by the amount of new research that continues to be published on the X-Factor.

 

And that¡¯s why I¡¯m writing to you today.

 

I want you and your family to discover what the X-Factor really is, and see first-hand the research I¡¯ve uncovered, BEFORE the big drug companies kill the story and prevent you from finding out.


I believe this long-forgotten nutrient will take the risk of heart disease, cancer, osteoporosis and Alzheimer¡¯s off the table.

 

But before I show you how the X-Factor treats and prevents heart disease, cancer and Alzheimer¡¯s, let me tell you about the X-Factor and your bones.


The connection to your bones was the first X-Factor breakthrough and it¡¯s at the center of this story.

 

Here¡¯s the evidence:
Forget About Calcium Supplements...
The X-Factor Keeps Your Bones as Strong as Steel

Americans consume more calcium than any other nation on Earth, yet we have the highest rates of bone loss and osteoporosis.
We also eat foods that have little to no trace of the X-Factor. That¡¯s a problem, because you need the X-Factor to build strong bones.
Without the X-Factor, it¡¯s impossible for calcium to ¡°stick¡± to your bones or make your bones stronger.

Here¡¯s why:
•Your body has dozens of proteins that need the X-Factor to ¡°activate¡± them.
•If you don¡¯t have the X-Factor in your blood, these proteins float through your blood in their ¡°inactive¡± form.

 

In Illustration #1(left) the green spiral proteins represent the ¡°inactive¡± form of the bone-building protein osteocalcin. In its inactive state, osteocalcin is not able to ¡°stick¡± to the bone.

In Illustration #2 (right) osteocalcin has bonded with the X-Factor (blue cells) and is now ¡°active¡± and able to ¡°stick¡± to the bone.   

 And that¡¯s bad news for your bones.
One of the proteins that is dependent on the X-Factor is called osteocalcin.
Osteocalcin is a bone-regulating protein that is controlled by the X-Factor. When osteocalcin is ¡°activated¡± by the X-Factor, it binds or ¡°sticks¡± calcium to the mineral portion of your bones, making them strong and resilient.


But when the X-Factor isn¡¯t there, osteocalcin stays ¡°inactive.¡±
When this happens, not only do your bones become weak and brittle because the calcium is not sticking to your bones, the inactive calcium floats through your blood and ¡°sticks¡± to places it doesn¡¯t belong... like your arteries and blood vessels.


As you¡¯ll see, the ¡°plaque¡± that clogs your arteries and puts you at a higher risk of heart attack is actually the inactive calcium that should have been used in your bones. That¡¯s why atherosclerosis is often called, ¡°hardening of your arteries.¡±

 

WARNING: Are You Taking Blood-Thinning Drugs?
Blood-thinning drugs like Warfarin (Coumadin¢ç) block the X-Factor and weaken its function in your body.
The result is a rapid acceleration of osteoporosis and plaque buildup in your arteries... with a much higher risk of bone loss and heart attack.
 

Studies published in the journals Blood and Archives of Internal Medicine show users of Coumadin¢ç suffer more bone fractures and show dramatically higher calcium deposition in their blood vessels and heart valves.
Other studies show blocking the X-Factor with blood thinners can cause cancer to spread more quickly to other organs or tissues. 
If you are taking blood thinners, work with your doctor to take the X-Factor along with your medication. 


 The facts are clear: When you¡¯re missing the X-Factor, your bone strength plummets, leaving you with a high risk of fractures, bone loss and osteoporosis.

 

Check out these studies:

•A landmark study published in the Journal of Bone and Mineral Research discovered that people with the highest levels of ¡°inactive¡± osteocalcin have a 500% higher risk of bone fracture.
•In a seven-year study, researchers found that elderly men and women with the highest intake of the X-Factor had a 65% lower risk of hip fracture than those with the lowest intake.
•A two-year Japanese study found the X-Factor lowered spine fractures by 52% in people with osteoporosis.
•Published in the American Journal of Clinical Nutrition, a ten-year study that followed over 10,000 women found that women with the lowest intake of the X-Factor had a 30% higher risk of hip fracture than women with a higher intake. 
•Experimental studies on animals revealed that the X-Factor improves bone architecture, increases bone mass and mechanical strength, stimulates the deposition of calcium and boosts resistance to fracture.


It¡¯s clear the X-Factor plays a central role in bone health. By protecting against bone loss that happens with age, and ensuring that calcium ¡°sticks¡± to your bones, the X-Factor is the ¡°unsung hero¡± that makes your bones almost unbreakable.
 

Even more revealing, doctors in Japan increasingly prescribe the X-Factor instead of drugs for bone loss.


So why would these doctors bypass drugs in favor of a simple nutrient? Studies published in the journal Nutrition and the American Journal of Clinical Nutrition found that...

 

The X-Factor by itself can stop the loss of bone density and in some cases can even
increase bone mass in people with osteoporosis.

 

It¡¯s no wonder calcium supplements on their own do NOTHING to protect your bones from becoming brittle and full of holes.


And drugs are no better.
A new study published in the Journal of American Medicine shows that drugs like Boniva, Fosamax and Reclast, which are supposed to make your bones ¡°stronger¡± actually increase your risk of fracture by 300% after 5 years.


You MUST have the X-Factor to stay active and on your feet. It¡¯s the long-forgotten nutrient that keeps your bones strong and resilient... and it does it naturally, with no side effects.

 
But your bones are just part of the story. As I mentioned above, the X-Factor is also critical for a healthy heart and clear blood vessels...

 

The X-Factor Scrubs Your Arteries Clean:
No More Plaque and No More Heart Attacks

New research is quickly redefining heart disease as a deficiency of the X-Factor.

In fact, the X-Factor may be the one nutrient your body needs to clear away years of artery-clogging plaque that skyrockets your risk of heart disease and heart attack.

 

Sound remarkable? Let¡¯s look at the evidence.

In the same way the X-Factor ¡°activates¡± the protein that makes calcium stick to your bones, the X-Factor activates another protein called matrix GLA-protein (MGP). The job of MGP is to stop the build up of calcium.

If you don¡¯t have the X-Factor to activate MGP, the ¡°inactive¡± form allows for a rapid build up of calcium in your blood vessels, which blocks the flow of blood to and from your heart. 

When osteocalcin (green spiral) stays inactive, it floats through your blood stream (1) and ¡°sticks¡± to places it doesn¡¯t belong, like the lining of your blood vessels (2).

Over time, the inactive osteocalcin hardens and combines with oxidized cholesterol to form the plaque that sticks to your blood vessels. This dangerous buildup raises your risk of heart attack and heart disease (right).
 
In animal studies, mice genetically bred to lack the MGP protein develop a wild and unrestrained buildup of plaque in their arteries that is so powerful they die within a few weeks of birth.

You need the X-Factor to activate MGP and put a stop to the buildup of plaque in your arteries.

The X-Factor also activates two other proteins that play a key role in plaque build up and heart health. One is called gas6, the other protein S.

When activated by the X-Factor, these two proteins clear away the dead cells and other debris that combine with calcium to form the deadly plaque that clogs your arteries.

 

Landmark Study Shows The X-Factor Cuts Your Risk of Dying of Heart Disease By More Than Half

The most important study to link the X-Factor to a lower risk of heart disease comes from the Netherlands.

 The Dutch trial followed 4,800 people for 7 years and it¡¯s considered a landmark study because it¡¯s one of the first large-scale, well-controlled clinical studies to show a clear connection between the X-Factor and heart disease.

The results, published by the American Society for Nutrition, revealed that people with the highest levels of the X-Factor experienced a 57% reduction of death from heart disease than those with the lowest levels.  

 Overall, the researchers found that the X-Factor:
•Lowered the risk of coronary artery disease by 57%
•Lowered the risk of severe calcium buildup in your arteries by 52%
•Lowered all-cause mortality by 26%
Look at that last number... the X-Factor lowers your risk of dying of ALL CAUSES -- not just heart disease -- by a whopping 26 percent.


And the news gets even better...

Researchers from the University of Maastricht recently showed that if you get your levels of the X-Factor high enough, you can actually reverse the buildup of plaque that is already in your arteries. 

In this promising animal study, researchers showed for the first time that plaque buildup in your blood vessels is not just preventable, it¡¯s reversible.

The reason is the X-Factor-dependent protein we mentioned earlier, MGP.

MGP is responsible for the reabsorption of calcium so that it doesn¡¯t ¡°stick¡± to places it doesn¡¯t belong.
 
These are sections of the blood vessels from the rats used in the study. In photo A, the dark area shows the buildup of calcium deposits in the rats NOT taking the X-Factor.

Photos B and C show the gradual disappearance of calcium deposits in the rats taking the X-Factor.

After 12 weeks, the rats taking the X-Factor(photo D) show almost no sign of calcium buildup, evidence that the X-Factor reversed the condition known as ¡°hardening of the arteries.¡±
 
By ¡°activating¡± MGP with high doses of the X-Factor, this reabsorption process kicks into high gear.

 In just 12 weeks, the mice taking the X-Factor saw a dramatic reduction of plaque buildup in their arteries.

Have a look at the pictures to the right: In photo A, the dark area shows the buildup of calcium deposits in the rats not taking the X-Factor.

In photos B and C, you can see the gradual disappearance of the plaque-causing calcium deposits in the rats taking vitamin K2.

After 12 weeks, the rats taking vitamin K2 showed a near-complete reversal, showing almost no residual calcium in their arteries, (photo D).

Hardening of the arteries, a condition once thought to be ¡°irreversible,¡± is now cured with the power of the X-Factor.

 

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