###Herbs for Pain Management ---By Cathy Wong, About.com Guide, Updated April 24, 2009
If you suffer from an inflammation-related condition such as arthritis, neck and back pain, or tendonitis, adding anti-inflammatory herbs to your health regimen may help you manage your pain. Although not as fast-acting as standard pain medication, such herbs may significantly diminish your pain when used regularly (especially when combined with daily exercise and the practice of relaxation techniques, both of which can provide pain reduction).
Keep in mind that anti-inflammatory herbs won't heal your condition itself, despite their pain-easing effects. Furthermore, addressing the cause of chronic inflammation is essential for working your way toward optimal health; not only known to generate pain, inflammation is a major risk factor for chronic diseases like cancer, cardiovascular disease, and diabetes.
Be sure to consult your primary care provider before using herbs, to avoid making common mistakes.
@@@Herbal Pain Relief
Here's a look at six inflammation-fighting herbs that may provide pain relief.
1) White Willow Bark
Containing aspirin-like compounds, this herb was found to be as effective as conventional medicine in lessening pain among people with mild to fairly severe knee and hip problems in a 2008 study. White willow bark may also alleviate acute back pain, joint pain, and osteoarthritis.
2) Boswellia
Sourced from a resin found in the bark of frankincense trees, boswellia has been shown to thwart chemical reactions involved in inflammation. Practitioners of ayurvedic medicine have long used boswellia to treat arthritis; the herb may also benefit people with inflammatory bowel disease.
3) Devil's Claw
Traditionally used to treat rheumatoid arthritis, devil's claw may also soothe pain resulting from osteoarthritis, tendonitis, and back and neck troubles. In a 2007 study of 259 people with rheumatic conditions, researchers found that 60% of study members either reduced or stopped their pain medication after eight weeks of taking devil's claw. The herb also appeared to improve the participants' quality of life.
4) Bromelain
An enzyme extracted from pineapple stems, bromelain reduces levels of prostaglandins, which are hormones that induce inflammation. Bromelain may benefit people with arthritis and conditions marked by musculoskeletal tension (such as TMJ syndrome), as well as those suffering trauma-related inflammation. What's more, the enzyme may promote healing in muscles and connective tissues.
5) Curcumin
Another ayurvedic remedy known to tame arthritis pain, curcumin is a compound found in the curry spice turmeric. In an animal-based study published in 2007, scientists discovered that curcumin can overpower pro-inflammatory proteins called cytokines. The compound may also help decrease pain associated with autoimmune disorders and tendonitis.
6) Ginger
While sipping ginger tea can help relieve cold-related congestion, supplementing with this warming herb may deliver long-lasting health effects. Research indicates that ginger may calm arthritis pain, possibly by lowering your prostaglandin levels. One 2005 study even suggests that ginger could reduce pain and inflammation more effectively than non-steroidal anti-inflammatory drugs (such as aspirin).
###What is Devil's Claw
Other Names: Harpagophytum procumbens, Grapple Plant, Wood Spider
Devil's claw is a plant native to southern Africa. Its name comes from the small hooks on the plant's fruit. The active ingredients in devil's claw are believed to be iridoid glycosides called harpagosides, which are found in the secondary root.
Most of the world's supply of devil's claw comes from Namibia, with lesser amounts coming from South Africa and Botswana.
@@@Why do people use devil's claw Devil's claw has been used for thousands of years in Africa for fever, rheumatoid arthritis, skin conditions, and conditions involving the gallbladder, pancreas, stomach and kidneys.
In the early 1900's, devil's claw was brought to Europe. It is used to improve digestion, as the bitter taste of devil's claw tea is thought to stimulate digestive juices.
However, the primary use of devil's claw today is for conditions that cause inflammation and pain: •Back pain •Neck pain •Rheumatoid arthritis •Osteoarthritis
According to a study in the Journal of Ethnopharmacology, sales of devil's claw in Germany were estimated to be $30 million euros in 2001, accounting for 74% of the prescriptions for rheumatism.
@@@What research has been done on devil's claw There is some evidence for the use of devil's claw, however one larger, randomized controlled trial found only a modest benefit.
•A German study examined the use of devil's claw for slight to moderate back, neck, and shoulder muscle tension and pain. In the 4-week study, 31 people took 480 mg twice a day and 32 people took a placebo. The results showed there was a significant reduction in pain in the people taking devil's claw compared to the placebo group.
•A study published in the journal Rheumatology compared a devil's claw extract providing 60 mg harpagosides a day and and 12.5 mg a day of the anti-inflammatory Vioxx (now off the market) for 6 weeks in 79 patients with an acute exacerbation of low back pain. Devil's claw was as effective as Vioxx in reducing pain.
•A study published in the journal Joint Bone Spine compared six 435 mg capsules of powdered devil's claw extract a day (which provides about 60 mg per day of harpagosides) with 100 mg a day of a European osteoarthritis drug called diacerhein in 122 patients with osteoarthritis of the knee or hip. After four months, devil's claw was as effective as the diacerhein at relieving pain, improving mobility, and reducing the need for back-up medication (such as anti-inflammatory and analgesic drugs). Although this sounds great, the results aren't as impressive in light of a 3-year placebo-controlled study found diacerhein was ineffective at reducing osteoarthritis symptoms.
•In a European Journal of Anaesthesiology 4-week study, 197 people with back pain rated at 5/10 or higher on a pain scale received a standardized daily dose of 50 mg or 100 mg harpagosides or placebo. Devil's claw seemed to reduce pain more than placebo. Devil's claw appears to work in the same way as Cox-2 anti-inflammatory drugs such as Celebrex and also produce changes in leukotrienes, another group of molecules involved in inflammation.
@@@Common doses
Devil's claw comes in capsule, tincture, and tea form.
For inflammation and pain, devil's claw is usually taken in capsule form. Based on the research, a daily dose of devil's claw should provide at least 50 mg of harpagosides per day (the amount of harpagosides in each devil's claw should be indicated on the bottle).
For indigestion and appetite loss, a tea is made by steeping 1 teaspoon of chopped or powdered dry root in 2 cups of boiling water for at least 20 minutes. It is then strained and cooled.
@@@Safety
•Devil's claw should not be used by people with gastric or duodenal ulcers.
•People with gallstones should consult a doctor before using devil's claw.
•People with diabetes or who are taking medication that affects their blood sugar should only use devil's claw under the supervision of a qualified health practitioner. In one study, devil's claw extract resulted in reductions in blood glucose in fasted normal and diabetic animals.
•Devil's claw should not be used by people who are or may be pregnant, as it is believed to cause uterine contractions.
@@@Side effects Devil's claw has been known to trigger an allergic reaction.
Some studies have reported stomach upset, a sensation of fullness, tinnitus (ringing in the ears), and headache.
In animal studies, there is a small risk of changes in blood pressure, heart rhythm, and blood glucose. One study found that it enhanced the action of GABA in the brain and depressed the central nervous system. It is not known whether these effects may also occur in humans.
@@@Sources Chrubasik S et al. "A randomized double-blind pilot study comparing Doloteffin and Vioxx in the treatment of low back pain." Rheumatology (Oxford). 42.1 (2003):141-8.
Chrubasik S et al. "Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double-blind study." European Journal of Anaesthesiology. 16.2 (1999):118-29.
Dougados M et al. "Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial. Evaluation of the Chondromodulating Effect of Diacerein in OA of the Hip." Arthritis and Rheumatism. 44.11 (2001):2539-47.
Gagnier JJ et al. "Herbal medicine for low back pain." Cochrane Database of Systematic Reviews. 19.2 (2006):CD004504.
Gobel H et al. "Effects of Harpagophytum procumbens LI 174 (devil's claw) on sensory, motor und vascular muscle reagibility in the treatment of unspecific back pain." Schmerz. 15.1 (2001):10-8.
Huang TH et al. "Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappaB activation." Journal of Ethnopharmacology. 104.1-2 (2006):149-55.
Leblan D et al. "Harpagophytum procumbens in the treatment of knee and hip osteoarthritis. Four-month results of a prospective, multicenter, double-blind trial versus diacerhein." Joint Bone Spine. 67.5 (2000):462-7.
Mahomed IM and Ojewole JA. "Anticonvulsant activity of Harpagophytum procumbens DC [Pedaliaceae] secondary root aqueous extract in mice." Brain Research Bulletin. 69.1 (2006):57-62.
Mahomed IM and Ojewole JA. "Analgesic, antiinflammatory and antidiabetic properties of Harpagophytum procumbens DC (Pedaliaceae) secondary root aqueous extract." Phytotherapy Research. 18.12 (2004):982-9.
Stewart KM and Cole D. "The commercial harvest of devil's claw (Harpagophytum spp.) in southern Africa: the devil's in the details Journal of Ethnopharmacology. 100.3 (2005):225-36.
Wegener T and Lupke NP. "Treatment of patients with arthrosis of hip or knee with an aqueous extract of devil's claw (Harpagophytum procumbens DC.)." Phytotherapy Research. 17.10 (2003):1165-72.
http://altmedicine.about.com/od/herbsupplementguide/a/DevilsClaw_2.htm
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###Cat's claw
Cat's Claw extract herb supplement health benefit and side effects, dosage and use for arthritis or osteoarthritis by Ray Sahelian, M.D. Does this herb have anti-inflammatory properties Does it benefit those with joint pain, arthritis, rheumatoid arthritis
Cat's claw (Uncaria tomentosa or Una do Gato) is a medicinal herb from the Amazon River basin that is widely used for inflammatory disorders. Cat's claw contains gluco indole alkaloids. This herb is promoted as having anti-cancer, anti-inflammatory, and for arthritis. In the traditional Peruvian medicine, hot aqueous extracts have been used for the treatment of a wide range of health problems, particularly digestive complaints and arthritis. What does the research say
Cats claw is a natural extract of the highest quality inner bark of authentic Uncaria tomentosa, an exciting herbal discovery from the Peruvian Rainforest. Also called Una de Gato, cat's claw herb has been used for hundreds of years by the native Ashanica Indians.
This is a concentrated water and alcohol extract standardized to contain a minimum of 3% total alkaloids (calculated as mitraphylline) and 15% total Polyphenols.
@@@Supplement Facts: Cat's Claw (Uncaria tomentosa) (inner bark) 334 mg of 15:1 standardized extract >-- daily min. 5gm powder to maximum 20gm powder(334mg extract - 1 to 4capsule)
Use with glucosamine and chondroitin, MSM, Boswellia , GSE, curcumin and Devil's claw for joint's health. Because joint pain is so debilitating, Glucosamine and Chondroitin alone are not enough. This powerful formula includes several additional herbal extracts and nutrients that play a role in joint health.
@@@Potential benefit of cat's claw herb and research studies
@Anti-inflammatory benefit Cat's claw is a remarkably potent inhibitor of TNFalpha production. The primary mechanism for cat's claw anti-inflammatory actions appears to be immunomodulation via suppression of TNFalpha synthesis. TNF stands for tumor necrosis factor.
@Antioxidant Cat's claw is an effective antioxidant. --Antioxidant properties of proanthocyanidins of Uncaria tomentosa bark decoction: a mechanism for anti-inflammatory activity.Phytochemistry. 2005. === Decoctions prepared from the bark of Uncaria tomentosa are widely used in the traditional Peruvian medicine for the treatment of several diseases, in particular as a potent anti-inflammatory agent. Therefore, the main purpose of this study was to determine if the well-known anti-inflammatory activity of cat's claw decoction was related with its reactivity with the oxidant species generated in the inflammatory process and to establish a relationship between such antioxidant ability and its phenolic composition. We observed that the cat's claw decoction prepared according to the traditional Peruvian medicine presented a potent radical scavenger activity, as suggested by its high capacity to reduce the free radical diphenylpicrylhydrazyl, and by its reaction with superoxide anion, peroxyl and hydroxyl radicals as well as with the oxidant species, hydrogen peroxide and hypochlorous acid. The phenolic profile shows the presence of proanthocyanidins (oligomeric procyanidins) and phenolic acids, mainly caffeic acid.
@Antitumor Cat's claw extracts exert a direct anti-proliferative activity on MCF7 (a breast cancer cell line).
@Arthritis This plant is an effective treatment for osteoarthritis and probably rheumatoid arthritis (see bottom of page). The species, U guianensis and U tomentosa are equiactive. They are effective antioxidants, but their anti-inflammatory properties may result from their ability to inhibit TNFalpha and to a lesser extent PGE2 production.
@Cancer prevention An extract of Uncaria tomentosa inhibiting cell division. Previous reports have demonstrated that extracts of the plant Uncaria tomentosa inhibit tumor cell proliferation and inflammatory responses. We have confirmed that cat's claw C-Med 100, a hot water extract of this plant, inhibits tumor cell proliferation albeit with variable efficiency. We extend these findings by showing that this extract also inhibits proliferation of normal mouse T and B lymphocytes and that the inhibition is not caused by toxicity or by induction of apoptosis. We provide direct evidence that cat's claw C-Med 100 inhibits nuclear factor kappa B (NF-kappa B) activity and propose that this at least partially causes the inhibition of proliferation.
@DNA repair Human volunteers who took cat's claw herb for 8 weeks had improved DNA repair. ---DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine. 2001. ===The Uncaria tomentosa water extracts (cat's claw, C-Med-100) have been shown to enhance DNA repair, mitogenic response and leukocyte recovery after chemotherapy-induced DNA damage in vivo. Twelve apparently healthy adults working in the same environment were randomly assigned into 3 groups with age and gender matched. One group was daily supplemented with a 250 mg tablet containing an aqueous extract of cat's claw, and another group with a 350 mg tablet, for 8 consecutive weeks. DNA repair after induction of DNA damage by a standard dose of hydrogen peroxide was measured 3 times before supplement and 3 times after the supplement for the last 3 weeks of the 8 week-supplement period. There were no drug-related toxic responses to cat's claw supplement when judged in terms of clinical symptoms, serum clinical chemistry, whole blood analysis and leukocyte differential counts. There was a statistically significant decrease of DNA damage and a concomitant increase of DNA repair in the supplement groups (250 and 350 mg/day) when compared with non-supplemented controls. There was also an increased tendency of PHA induced lymphocyte proliferation in the treatment groups. Taken together, this trial has confirmed the earlier results obtained in the rat model when estimating DNA repair enhancement by cat's claw.
@Immune system influence ---In vitro effects of two extracts and two pure alkaloid preparations of Uncaria tomentosa on peripheral blood mononuclear cells.Planta Med. 2004. ===In this study, the effects of two cat's claw extracts and two mixtures of tetracyclic and pentacyclic oxindole alkaloids were investigated in freshly isolated human peripheral blood mononuclear cells (PBMC) stimulated with the mitogens phytohaemagglutinin (PHA) and concanavalin A (Con A) in vitro. These data demonstrate that cat's claw extracts and mixtures of alkaloids modulate the immunobiochemical pathways induced by interferon-gamma. The findings imply a potential application of the cat's claw extracts as immunoregulators and would be in line with observations in patients using these extracts.
@Memory-Altzheimer Cat's claw herb total alkaloids exert a beneficial effect on memory impairment induced by the dysfunction of cholinergic systems in the brain and that the effect of the total alkaloids is partly attributed to the oxindole alkaloids tested.
@@@Rheumatoid arthritis ---Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of uncaria tomentosa for the treatment of rheumatoid arthritis.J Rheumatol. 2002. ===To evaluate safety and clinical efficacy of a plant extract from the pentacyclic chemotype of Uncaria tomentosa (cat's claw) in patients with active rheumatoid arthritis. Forty patients undergoing sulfasalazine or hydroxychloroquine treatment were enrolled in a randomized 52 week study. During the first phase (24 weeks, double blind, placebo controlled), patients were treated with cats claw extract or placebo. In the second phase (28 weeks) all patients received the plant extract. Twenty-four weeks of treatment with the cats claw extract resulted in a reduction of the number of painful joints compared to placebo (by 53% vs 24%). Patients receiving the cat's claw extract only during the second phase experienced a reduction in the number of painful and swollen joints and the Ritchie Index compared to the values after 24 weeks of placebo. Only minor side effects were observed. This small preliminary study demonstrates relative safety and modest benefit to the tender joint count of a highly purified extract from cat's claw in patients with active rheumatoid arthritis taking sulfasalazine or hydroxychloroquine.
@@@Safety, side effects, toxicity, risks As of 2011 no major safety issues have been mentioned in the medical literature and no major side effects have been reported. However, as more people use this herbal product adverse events could be found.
@@@Substances in the plant Oleanan-type triterpenes and cincholic acid glycosides along with alkaloids such as mitraphylline and polyphenols.
@@@More about Cat's Claw Generations of Ashaninka Indians have used cat's claw in the Amazon rainforest. Cat's claw is a woody vine that gets it name from the two curved thorns at the base of each leaf. This plant grows wild in the Peruvian rain forest where is grows into the trees. The inner bark of the vine contains the same beneficial properties as the root and is the preferred part since it can be gathered without destroying the plant.
@@@Cat's Claw Laboratory studies ---Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content.Phytomedicine. 2002. ===Cat's claw is an herbal medicine from the Amazon that is used widely to treat inflammatory disorders. The purpose of this study was to characterize the antioxidative and antiinflammatory properties of cat's claw, Uncaria tomentosa and Uncaria guianensis. These results indicate that while both species of cat's claw provide effective antioxidant and anti-inflammatory activities, U. guianensis is more potent. In conclusion, the presence of oxindole or pentacyclic alkaloids did not influence the antioxidant and anti-inflammatory properties of cat's claw.
---The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line. Anticancer Res. 2001. ===Uncaria tomentosa is widely used in South-American folk medicine for the treatment of cancer, arthritis, gastritis and epidemic diseases. Extracts of the plant have been shown to possess cytostatic and anti-inflammatory activity as well as mutagenic and antimutagenic properties. However, to date no studies have been carried out to verify the direct antitumor activity of the cat's claw extracts. The present study investigates the effects of some extracts and their chromatographic fractions from the bark of cat's claw on the growth of a human breast cancer cell line (MCF7). Our data indicated that, in addition to the antimutagenic activity, cat's claw extracts and fractions exert a direct antiproliferative activity on MCF7.
@@@Emails ---Having read somewhere that Cat's Claw supplement is helpful in cases of food sensitivity, and having a husband with regular bad bouts of gout I suggested he try it, since everyone always mentions various foods as being the cause of gout. He takes one capsule per day and hasn't had a trace of gout for two years.
---Please let me know how cat's claw supplement might effect an insulin dependant diabetic. I have been using Joint Power RX with much success, thank you.
---Thank you for the feedback. We did a medical research search and did not come up with any information regarding the influence of cat's claw on blood sugar or diabetes. Cat's claw may have an influence, but we just have not seen such research.
---In March of 2010 Dr. Oz from The Oz Show, had a segment on the benefits of this herb as an anti-inflammatory natural product. Were the claims made on the Dr. Oz show accurate Although lab studies indicate that this herb has such potential, as of March 2010 I have seen only preliminary human studies regarding the use of this herb reduces symptoms of arthritis, rheumatoid arthritis, or other conditions involving inflammation. I await the results of additional investigations to have a clearer idea regarding benefits, dosage, and long term safety.
@@@Other popular products in health food stores NOW Foods buy Cat's Claw "5000" supplement extract. Cat's Claw "5000" is a concentrated water and alcohol extract standardized to contain a minimum of 3% total alkaloids (calculated as mitraphylline) and 15% total Polyphenols.
@@@For hundreds of years a rather remarkable plant-Cat's Claw- has been revered and used by the indian natives of the Peruvian Amazon to "cure" cancer, arthritis, gastritis, ulcers, and female hormonal imbalances.
Researchers have determined that this plant, uncaria tomentosa, more commonly called "cat's claw," contains a wealth of beneficial phytochemical compounds: alkaloids, proanthocyanidins, polyphenols, triterpines, and plant sterols. Because of these compounds, cat's claw is a powerful cellular reconstitutor, displaying significant antibacterial, antiviral, antifungal, antitumor, anti-inflammatory, and anti-oxidant properties.
According to the available research and experience of doctors working in Peru, Germany, Austria, and the United States, cat's claw may be helpful in the treatment of: cancer; arthritis; bursitis; rheumatism; all forms of herpes; allergies; asthma; systemic candidiasis; acne; diabetes; lupus; prostatitis; chronic fatigue syndrome; PMS; irregularities of the female cycle; environmental toxin poisoning; organic depression; and those infected with the HIV virus. Evidence also suggests that cat's claw may be effective in the treatment of numerous stomach and bowel disorders including.
The most exciting research has been the work of Dr. Klaus Keplinger, an Austrian scientist who has obtained two United States patents for isolating the alkaloids responsible for enhancing phagocytosis. This has resulted in the development of a pharmaceutical which is now being used in Austria and Germany to combat the progression of cancer and AIDS. Unfortunately, the pharmaceutical is not available in the US, but the herb is available both in tea and in capsule form.
Traditionally in Peru, a decoction is made by boiling the bark and/or root for about an hour and then drinking four or more cups of tea per day. When using capsules, three to six grams per day is considered therapeutic. However, as much as 20 grams per day might be used for several weeks at a time to treat very advanced stages of pathology.
Dr. Satya Ambrose, ND, the co-founder of the Oregon College of Oriental Medicine, has been using the bark in capsule form with some of her patients for the past several months. She told me of excellent results with Crohn's disease, ulcers, asthma, and fibromyalgia. Within the last year, I have personally heard of other successes with lupus, lung cancer, prostatitis, and one patient who was able to reverse and overcome Kaposi's sarcoma, a rare form of skin cancer associated with AIDS.
Over the last year I, my wife, children, friends, and associates have found the herb to be effective at knocking out the flu, clearing up sinus, ear, and upper respiratory infections, canker sores, lower back pain associated with arthritis, and eliminating the tired, sore muscles associated with heavy physical work and exercise. I was even able to clear up a case of athlete's foot by putting the powdered bark between the infected toes, and my daughter's conjunctivitis by putting drops of the tea in her eyes several times over the course of two days.
Because of my research and first hand experience in using this wondrous and remarkable herb, I have come to believe that cat's claw is an effective natural remedy for many of today's serious health problems.
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